Cyclic comonomers for the synthesis of carboxylic acid and amine functionalized poly(L-lactic acid).

نویسندگان

  • Markus Heiny
  • V Prasad Shastri
چکیده

Degradable aliphatic polyesters such as poly(lactic acid) are widely used in biomedical applications, however, they lack functional moieties along the polymer backbone that are amenable for functionalization reactions or could be the basis for interactions with biological systems. Here we present a straightforward route for the synthesis of functional α-ω epoxyesters as comonomers for lactide polymerization. Salient features of these highly functionalized epoxides are versatility in functionality and a short synthetic route of less than four steps. The α-ω epoxyesters presented serve as a means to introduce carboxylic acid and amine functional groups into poly(lactic acid) polymers via ring-opening copolymerization.

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عنوان ژورنال:
  • Molecules

دوره 20 3  شماره 

صفحات  -

تاریخ انتشار 2015